Homo sapiens Gene: KRT1
Summary
InnateDB Gene IDBG-34896.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT1
Gene Name keratin 1
Synonyms CK1; EHK; EHK1; EPPK; K1; KRT1A; NEPPK;
Species Homo sapiens
Ensembl Gene ENSG00000167768
Encoded Proteins
keratin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52674736-52680407
Strand Reverse strand
Band q13.13
Transcripts
ENST00000252244 ENSP00000252244
ENST00000548765
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 66 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0001867 complement activation, lectin pathway
GO:0001895 retina homeostasis
GO:0006979 response to oxidative stress
GO:0042730 fibrinolysis
GO:0045765 regulation of angiogenesis
GO:0050728 negative regulation of inflammatory response
GO:0061436 establishment of skin barrier
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005856 cytoskeleton
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of nuclear beta catenin signaling and target gene transcription
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.80828
RefSeq NM_006121
HUGO
OMIM
CCDS CCDS8836
HPRD 00763
IMGT
EMBL
GenPept
RNA Seq Atlas