InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYP4F12

Summary

InnateDB Gene

IDBG-34899.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP4F12

Gene Name

cytochrome P450, family 4, subfamily F, polypeptide 12

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000186204

Encoded Proteins

IDBP-34901

cytochrome P450, family 4, subfamily F, polypeptide 12

IDBP-475351

cytochrome P450, family 4, subfamily F, polypeptide 12

IDBP-587805

cytochrome P450, family 4, subfamily F, polypeptide 12

IDBP-596869

cytochrome P450, family 4, subfamily F, polypeptide 12

IDBP-598537

cytochrome P450, family 4, subfamily F, polypeptide 12

IDBP-599589

cytochrome P450, family 4, subfamily F, polypeptide 12

IDBP-602871

cytochrome P450, family 4, subfamily F, polypeptide 12

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid; however, its physiological function has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:15672757-15697174

Strand

Forward strand

Band

p13.12

Transcripts

ENST00000324632	ENSP00000321821
ENST00000451750
ENST00000430608
ENST00000517734	ENSP00000430849
ENST00000518629
ENST00000550308	ENSP00000448998
ENST00000547332	ENSP00000448560
ENST00000547471
ENST00000548237	ENSP00000446812
ENST00000548501
ENST00000549622
ENST00000548435	ENSP00000449703
ENST00000546792
ENST00000550264
ENST00000551607	ENSP00000447922
ENST00000550627
ENST00000546608

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008392	arachidonic acid epoxygenase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685	alkane 1-monooxygenase activity
GO:0020037	heme binding
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0050051	leukotriene-B4 20-monooxygenase activity
GO:0070330	aromatase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001676	long-chain fatty acid metabolic process
GO:0003091	renal water homeostasis
GO:0003095	pressure natriuresis
GO:0006805	xenobiotic metabolic process
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0030195	negative regulation of blood coagulation
GO:0036101	leukotriene B4 catabolic process
GO:0042360	vitamin E metabolic process
GO:0042371	vitamin K biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055078	sodium ion homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043231	intracellular membrane-bounded organelle