Homo sapiens Gene: CYP4F12
Summary
InnateDB Gene IDBG-34899.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP4F12
Gene Name cytochrome P450, family 4, subfamily F, polypeptide 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186204
Encoded Proteins
cytochrome P450, family 4, subfamily F, polypeptide 12
cytochrome P450, family 4, subfamily F, polypeptide 12
cytochrome P450, family 4, subfamily F, polypeptide 12
cytochrome P450, family 4, subfamily F, polypeptide 12
cytochrome P450, family 4, subfamily F, polypeptide 12
cytochrome P450, family 4, subfamily F, polypeptide 12
cytochrome P450, family 4, subfamily F, polypeptide 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid; however, its physiological function has not been determined. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:15672757-15697174
Strand Forward strand
Band p13.12
Transcripts
ENST00000324632 ENSP00000321821
ENST00000451750
ENST00000430608
ENST00000517734 ENSP00000430849
ENST00000518629
ENST00000550308 ENSP00000448998
ENST00000547332 ENSP00000448560
ENST00000547471
ENST00000548237 ENSP00000446812
ENST00000548501
ENST00000549622
ENST00000548435 ENSP00000449703
ENST00000546792
ENST00000550264
ENST00000551607 ENSP00000447922
ENST00000550627
ENST00000546608
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0008392 arachidonic acid epoxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685 alkane 1-monooxygenase activity
GO:0020037 heme binding
GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0050051 leukotriene-B4 20-monooxygenase activity
GO:0070330 aromatase activity
Biological Process
GO:0000038 very long-chain fatty acid metabolic process
GO:0001676 long-chain fatty acid metabolic process
GO:0003091 renal water homeostasis
GO:0003095 pressure natriuresis
GO:0006805 xenobiotic metabolic process
GO:0017144 drug metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0019373 epoxygenase P450 pathway
GO:0030195 negative regulation of blood coagulation
GO:0036101 leukotriene B4 catabolic process
GO:0042360 vitamin E metabolic process
GO:0042371 vitamin K biosynthetic process
GO:0044281 small molecule metabolic process
GO:0055078 sodium ion homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Cytochrome P450 - arranged by substrate type pathway
Fatty acids pathway
Metabolism pathway
Biological oxidations pathway
Eicosanoids pathway
Phase 1 - Functionalization of compounds pathway
KEGG
INOH
Tryptophan degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.131459
RefSeq NM_023944 XM_005260038
HUGO
OMIM
CCDS CCDS42517
HPRD 07102
IMGT
EMBL
GenPept
RNA Seq Atlas