InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYP4F12

Summary

InnateDB Protein

IDBP-587805.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYP4F12

Protein Name

cytochrome P450, family 4, subfamily F, polypeptide 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000448998

InnateDB Gene

IDBG-34899 (CYP4F12)

Protein Structure

UniProt Annotation

Function

Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in small intestine, liver, colon and heart. {ECO:0000269PubMed:11162607, ECO:0000269PubMed:11162645}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005506	iron ion binding
GO:0008392	arachidonic acid epoxygenase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685	alkane 1-monooxygenase activity
GO:0020037	heme binding
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0050051	leukotriene-B4 20-monooxygenase activity
GO:0070330	aromatase activity

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001676	long-chain fatty acid metabolic process
GO:0003091	renal water homeostasis
GO:0003095	pressure natriuresis
GO:0006805	xenobiotic metabolic process
GO:0017144	drug metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0019373	epoxygenase P450 pathway
GO:0030195	negative regulation of blood coagulation
GO:0036101	leukotriene B4 catabolic process
GO:0042360	vitamin E metabolic process
GO:0042371	vitamin K biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055078	sodium ion homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV

PFAM

PF00067

PRINTS

PR00385
PR00463
PR00464
PR00465

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9HCS2