Version 5.4
Homo sapiens Gene: RGMB
Summary
InnateDB Gene IDBG-35165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGMB
Gene Name RGM domain family, member B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174136
Encoded Proteins
IDBP-35167
RGM domain family, member B
IDBP-485386
RGM domain family, member B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21187450
RGMB is highly expressed in macrophages and negatively regulates IL6 expression in a BMP ligand-dependent manner via MAPK and ERK pathway. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21187450
[Mus musculus] Rgmb is highly expressed in macrophages and negatively regulates Il6 expression in a BMP ligand-dependent manner via MAPK and ERK pathway.
Entrez Gene
Summary RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:98768650-98798643
Strand Forward strand
Band q15
Transcripts
ENST00000308234 ENSP00000308219
ENST00000434027
ENST00000504776
ENST00000505265
ENST00000507054
ENST00000513185 ENSP00000423256
ENST00000508978
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0042802 identical protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0030509 BMP signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0045121 membrane raft
GO:0046658 anchored component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000048027
View Gene Order
ENSBTAG00000011864
Not yet available
Pathways
NETPATH
REACTOME
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.526902 Hs.600209 Hs.607986 Hs.636047
RefSeq NM_001012761 XM_005271966
HUGO
OMIM
CCDS CCDS47251
HPRD 15243
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca