Homo sapiens Gene: RGMB
Summary
InnateDB Gene IDBG-35165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGMB
Gene Name RGM domain family, member B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000174136
Encoded Proteins
RGM domain family, member B
RGM domain family, member B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
RGMB is highly expressed in macrophages and negatively regulates IL6 expression in a BMP ligand-dependent manner via MAPK and ERK pathway. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Rgmb is highly expressed in macrophages and negatively regulates Il6 expression in a BMP ligand-dependent manner via MAPK and ERK pathway.
Entrez Gene
Summary RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:98768650-98798643
Strand Forward strand
Band q15
Transcripts
ENST00000308234 ENSP00000308219
ENST00000434027
ENST00000504776
ENST00000505265
ENST00000507054
ENST00000513185 ENSP00000423256
ENST00000508978
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0042802 identical protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007411 axon guidance
GO:0030509 BMP signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0045121 membrane raft
GO:0046658 anchored component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Axon guidance pathway
Netrin-1 signaling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL J3KNF6
UniProt Splice Variant
Entrez Gene 285704
UniGene Hs.526902 Hs.600209 Hs.607986 Hs.636047
RefSeq NM_001012761 XM_005271966
HUGO HGNC:26896
OMIM 612687
CCDS CCDS47251
HPRD 15243
IMGT
EMBL AC008522 AK074887 BC067736
GenPept AAH67736 BAC11268
RNA Seq Atlas 285704