Version 5.4
Homo sapiens Gene: TPM4
Summary
InnateDB Gene IDBG-35241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPM4
Gene Name tropomyosin 4
Synonyms HEL-S-108
Species Homo sapiens
Ensembl Gene ENSG00000167460
Encoded Proteins
IDBP-35243
tropomyosin 4
IDBP-35245
tropomyosin 4
IDBP-761229
IDBP-765689
IDBP-762486
IDBP-761817
IDBP-760123
IDBP-762867
IDBP-764866
IDBP-762347
IDBP-766088
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:16067021-16103005
Strand Forward strand
Band p13.12
Transcripts
ENST00000344824 ENSP00000345230
ENST00000300933 ENSP00000300933
ENST00000590180
ENST00000589897 ENSP00000466158
ENST00000588032 ENSP00000467319
ENST00000591226
ENST00000586499 ENSP00000468246
ENST00000586193
ENST00000586833 ENSP00000467087
ENST00000588483 ENSP00000466106
ENST00000588410 ENSP00000467250
ENST00000591645
ENST00000592138 ENSP00000466654
ENST00000587201
ENST00000588507 ENSP00000467558
ENST00000592822 ENSP00000468010
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0008307 structural constituent of muscle
Biological Process
GO:0001649 osteoblast differentiation
GO:0006928 cellular component movement
GO:0006936 muscle contraction
GO:0030049 muscle filament sliding
Cellular Component
GO:0001725 stress fiber
GO:0002102 podosome
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005862 muscle thin filament tropomyosin
GO:0016020 membrane
GO:0030863 cortical cytoskeleton
GO:0031941 filamentous actin
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_20558
Smooth Muscle Contraction pathway
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
KEGG
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL K7EQW8
UniProt Splice Variant
Entrez Gene 7171
UniGene Hs.449194 Hs.678971 Hs.707554
RefSeq NM_001145160 NM_003290
HUGO HGNC:12013
OMIM 600317
CCDS CCDS12338 CCDS46007
HPRD 11734
IMGT
EMBL AC008894
GenPept
RNA Seq Atlas 7171

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca