Homo sapiens Gene: NAMPT
Summary
InnateDB Gene IDBG-35259.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAMPT
Gene Name nicotinamide phosphoribosyltransferase
Synonyms 1110035O14Rik; PBEF; PBEF1; VF; VISFATIN;
Species Homo sapiens
Ensembl Gene ENSG00000105835
Encoded Proteins
nicotinamide phosphoribosyltransferase
nicotinamide phosphoribosyltransferase
nicotinamide phosphoribosyltransferase
nicotinamide phosphoribosyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
NAMPT secretion is enhanced by extracellular ATP in LPS-primed monocytes.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Nampt secretion is enhanced by extracellular ATP in LPS-primed monocytes. (Demonstrated in human)
Entrez Gene
Summary This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:106248285-106286326
Strand Reverse strand
Band q22.3
Transcripts
ENST00000222553 ENSP00000222553
ENST00000354289 ENSP00000346242
ENST00000393618
ENST00000441045
ENST00000424768 ENSP00000390591
ENST00000417537 ENSP00000390896
ENST00000463871
ENST00000491027
ENST00000467730
ENST00000484527
ENST00000486949
ENST00000489358
ENST00000489732
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0042803 protein homodimerization activity
GO:0047280 nicotinamide phosphoribosyltransferase activity
Biological Process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006769 nicotinamide metabolic process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007565 female pregnancy
GO:0008284 positive regulation of cell proliferation
GO:0009435 NAD biosynthetic process
GO:0014070 response to organic cyclic compound
GO:0019674 NAD metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Circadian Clock pathway
Defective HLCS causes multiple carboxylase deficiency pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Metabolism of water-soluble vitamins and cofactors pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Nicotinamide salvaging pathway
Defective CD320 causes methylmalonic aciduria pathway
Defects in cobalamin (B12) metabolism pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Nicotinate metabolism pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Defects in biotin (Btn) metabolism pathway
Defective BTD causes biotidinase deficiency pathway
Defective GIF causes intrinsic factor deficiency pathway
Defects in vitamin and cofactor metabolism pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Metabolism pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Disease pathway
Metabolism of vitamins and cofactors pathway
KEGG
Nicotinate and nicotinamide metabolism pathway
INOH
Nicotinate Nicotinamide metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.489615 Hs.611739 Hs.611792 Hs.641730
RefSeq NM_005746 XM_005250100
HUGO
OMIM
CCDS CCDS5737
HPRD 09938
IMGT
EMBL
GenPept
RNA Seq Atlas