InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NAMPT

Summary

InnateDB Protein

IDBP-35261.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NAMPT

Protein Name

nicotinamide phosphoribosyltransferase

Synonyms

1110035O14Rik; PBEF; PBEF1; VF; VISFATIN;

Species

Homo sapiens

Ensembl Protein

ENSP00000222553

InnateDB Gene

IDBG-35259 (NAMPT)

Protein Structure

UniProt Annotation

Function

Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. {ECO:0000269PubMed:24130902}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}. Secreted. Note=Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum.

Disease Associations

Tissue Specificity

Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008144	drug binding
GO:0042803	protein homodimerization activity
GO:0047280	nicotinamide phosphoribosyltransferase activity

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006769	nicotinamide metabolic process
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007565	female pregnancy
GO:0008284	positive regulation of cell proliferation
GO:0009435	NAD biosynthetic process
GO:0014070	response to organic cyclic compound
GO:0019674	NAD metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002638 Quinolinate phosphoribosyl transferase, C-terminal
IPR007229 Nicotinate phosphoribosyltransferase family
IPR016471 Nicotinamide phosphoribosyl transferase

PFAM

PF01729
PF04095

PRINTS

PIRSF

PIRSF000484
PIRSF005943

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P43490