Homo sapiens Gene: RAB8A
Summary
InnateDB Gene IDBG-35329.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB8A
Gene Name RAB8A, member RAS oncogene family
Synonyms MEL; RAB8;
Species Homo sapiens
Ensembl Gene ENSG00000167461
Encoded Proteins
RAB8A, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Rab8a interacts with Pik3cg to regulate Akt signalling generated by surface Tlr4.
Entrez Gene
Summary The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%%, 96%%, and 51%% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:16111629-16134234
Strand Forward strand
Band p13.11
Transcripts
ENST00000300935 ENSP00000300935
ENST00000587156
ENST00000589697
ENST00000586682 ENSP00000467501
ENST00000590899
ENST00000588105
ENST00000592971
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 54 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0017137 Rab GTPase binding
GO:0019003 GDP binding
GO:0019901 protein kinase binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006904 vesicle docking involved in exocytosis
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007409 axonogenesis
GO:0015031 protein transport
GO:0032869 cellular response to insulin stimulus
GO:0032880 regulation of protein localization
GO:0042384 cilium assembly
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048210 Golgi vesicle fusion to target membrane
GO:0051223 regulation of protein transport
GO:0061024 membrane organization
GO:0072659 protein localization to plasma membrane
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030140 trans-Golgi network transport vesicle
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0031513 nonmotile primary cilium
GO:0036064 ciliary basal body
GO:0043025 neuronal cell body
GO:0045335 phagocytic vesicle
GO:0055037 recycling endosome
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
G2/M Transition pathway
Translocation of GLUT4 to the plasma membrane pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
Membrane Trafficking pathway
KEGG
Pancreatic secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_005370
HUGO
OMIM
CCDS CCDS12339
HPRD 01296
IMGT
EMBL
GenPept
RNA Seq Atlas