Version 5.4
Homo sapiens Gene: EIF4B
Summary
InnateDB Gene IDBG-35510.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4B
Gene Name eukaryotic translation initiation factor 4B
Synonyms EIF-4B; PRO1843
Species Homo sapiens
Ensembl Gene ENSG00000063046
Encoded Proteins
IDBP-35512
eukaryotic translation initiation factor 4B
IDBP-375885
eukaryotic translation initiation factor 4B
IDBP-375886
eukaryotic translation initiation factor 4B
IDBP-597368
eukaryotic translation initiation factor 4B
IDBP-590382
eukaryotic translation initiation factor 4B
IDBP-599776
eukaryotic translation initiation factor 4B
IDBP-588651
eukaryotic translation initiation factor 4B
IDBP-600867
eukaryotic translation initiation factor 4B
IDBP-585524
eukaryotic translation initiation factor 4B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53006158-53042209
Strand Forward strand
Band q13.13
Transcripts
ENST00000262056 ENSP00000262056
ENST00000416762 ENSP00000412530
ENST00000420463 ENSP00000388806
ENST00000551527
ENST00000549077 ENSP00000448399
ENST00000549645
ENST00000551002 ENSP00000447192
ENST00000550704 ENSP00000448365
ENST00000549481 ENSP00000449746
ENST00000552490 ENSP00000450324
ENST00000550390 ENSP00000448980
ENST00000550025
ENST00000553209
ENST00000549592
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0008286 insulin receptor signaling pathway
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005829 cytosol
GO:0016281 eukaryotic translation initiation factor 4F complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058655
View Gene Order
ENSBTAG00000006883
Not yet available
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_6772
S6K1 signalling pathway
REACT_6754
S6K1-mediated signalling pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_20514
Deadenylation of mRNA pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_456
PKB-mediated events pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_6964
mTORC1-mediated signalling pathway
REACT_1014
Translation pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_17015
Metabolism of proteins pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_71
Gene Expression pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa03013
RNA transport pathway
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.618114 Hs.648394 Hs.702041 Hs.729387
RefSeq NM_001300821 NM_001417 XM_005268709 XM_006719274
HUGO
OMIM
CCDS CCDS41788 CCDS73474
HPRD 04892
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca