Homo sapiens Gene: EIF4B
Summary
InnateDB Gene IDBG-35510.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4B
Gene Name eukaryotic translation initiation factor 4B
Synonyms EIF-4B; PRO1843;
Species Homo sapiens
Ensembl Gene ENSG00000063046
Encoded Proteins
eukaryotic translation initiation factor 4B
eukaryotic translation initiation factor 4B
eukaryotic translation initiation factor 4B
eukaryotic translation initiation factor 4B
eukaryotic translation initiation factor 4B
eukaryotic translation initiation factor 4B
eukaryotic translation initiation factor 4B
eukaryotic translation initiation factor 4B
eukaryotic translation initiation factor 4B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53006158-53042209
Strand Forward strand
Band q13.13
Transcripts
ENST00000262056 ENSP00000262056
ENST00000416762 ENSP00000412530
ENST00000420463 ENSP00000388806
ENST00000551527
ENST00000549077 ENSP00000448399
ENST00000549645
ENST00000551002 ENSP00000447192
ENST00000550704 ENSP00000448365
ENST00000549481 ENSP00000449746
ENST00000552490 ENSP00000450324
ENST00000550390 ENSP00000448980
ENST00000550025
ENST00000553209
ENST00000549592
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 70 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0008286 insulin receptor signaling pathway
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005829 cytosol
GO:0016281 eukaryotic translation initiation factor 4F complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Eukaryotic Translation Initiation pathway
PKB-mediated events pathway
Deadenylation-dependent mRNA decay pathway
mTOR signalling pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
S6K1 signalling pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
mTORC1-mediated signalling pathway
Translation pathway
Signal Transduction pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
Translation initiation complex formation pathway
S6K1-mediated signalling pathway
Metabolism of proteins pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
Cap-dependent Translation Initiation pathway
Deadenylation of mRNA pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Ribosomal scanning and start codon recognition pathway
Signaling by Insulin receptor pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
KEGG
RNA transport pathway
mTOR signaling pathway pathway
INOH
PID BIOCARTA
Mtor signaling pathway [Biocarta view]
PID NCI
mTOR signaling pathway
Cross-References
SwissProt P23588
TrEMBL B4DS13 E7EX17 F8VP89 F8VRU1 F8VSC7 F8VX11 F8VYE9 F8W0K0
UniProt Splice Variant
Entrez Gene 1975
UniGene Hs.618114 Hs.648394 Hs.702041 Hs.729387
RefSeq NM_001300821 NM_001417 XM_005268709 XM_006719274
HUGO HGNC:3285
OMIM 603928
CCDS CCDS41788 CCDS73474
HPRD
IMGT
EMBL AB076839 AC068888 AK222528 AK299526 BC073139 BC073154 BC098437 CH471054 CR456958 X55733
GenPept AAH73139 AAH73154 AAH98437 BAB82380 BAD96248 BAG61475 CAA39265 CAG33239 EAW96657
RNA Seq Atlas 1975