Version 5.4
Homo sapiens Gene: TENC1
Summary
InnateDB Gene IDBG-35574.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TENC1
Gene Name tensin like C1 domain containing phosphatase (tensin 2)
Synonyms C1-TEN; C1TEN; TNS2
Species Homo sapiens
Ensembl Gene ENSG00000111077
Encoded Proteins
IDBP-35576
tensin like C1 domain containing phosphatase (tensin 2)
IDBP-35578
tensin like C1 domain containing phosphatase (tensin 2)
IDBP-35582
tensin like C1 domain containing phosphatase (tensin 2)
IDBP-604130
tensin like C1 domain containing phosphatase (tensin 2)
IDBP-604131
tensin like C1 domain containing phosphatase (tensin 2)
IDBP-604132
tensin like C1 domain containing phosphatase (tensin 2)
IDBP-604134
tensin like C1 domain containing phosphatase (tensin 2)
IDBP-812076
tensin like C1 domain containing phosphatase (tensin 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53046969-53064372
Strand Forward strand
Band q13.13
Transcripts
ENST00000314276 ENSP00000319756
ENST00000314250 ENSP00000319684
ENST00000379902 ENSP00000369232
ENST00000549498
ENST00000551302
ENST00000552403
ENST00000549311
ENST00000546602 ENSP00000449363
ENST00000552570 ENSP00000447021
ENST00000549700 ENSP00000449361
ENST00000551693
ENST00000549789
ENST00000547223
ENST00000546759
ENST00000551583
ENST00000546772 ENSP00000449165
ENST00000550660
ENST00000552168
ENST00000550048
ENST00000602335 ENSP00000473388
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001822 kidney development
GO:0008285 negative regulation of cell proliferation
GO:0014850 response to muscle activity
GO:0016311 dephosphorylation
GO:0019725 cellular homeostasis
GO:0032963 collagen metabolic process
GO:0035264 multicellular organism growth
GO:0035556 intracellular signal transduction
GO:0048871 multicellular organismal homeostasis
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037003
View Gene Order
ENSBTAG00000006904
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.6147
RefSeq NM_015319 NM_170754 NM_198316
HUGO
OMIM
CCDS CCDS8842 CCDS8843 CCDS8844
HPRD 16256
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca