InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TENC1

Summary

InnateDB Protein

IDBP-35576.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TENC1

Protein Name

tensin like C1 domain containing phosphatase (tensin 2)

Synonyms

C1-TEN; C1TEN; TNS2;

Species

Homo sapiens

Ensembl Protein

ENSP00000319756

InnateDB Gene

IDBG-35574 (TENC1)

Protein Structure

UniProt Annotation

Function

Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling. {ECO:0000269PubMed:15817639}.

Subcellular Localization

Cell junction, focal adhesion {ECO:0000269PubMed:11792844}. Cell membrane {ECO:0000269PubMed:11792844}; Peripheral membrane protein {ECO:0000269PubMed:11792844}; Cytoplasmic side {ECO:0000269PubMed:11792844}. Note=Detected at the end of actin stress fibers.

Disease Associations

Tissue Specificity

Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine. {ECO:0000269PubMed:11792844, ECO:0000269PubMed:12470648}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001822	kidney development
GO:0008285	negative regulation of cell proliferation
GO:0014850	response to muscle activity
GO:0016311	dephosphorylation
GO:0019725	cellular homeostasis
GO:0032963	collagen metabolic process
GO:0035264	multicellular organism growth
GO:0035556	intracellular signal transduction
GO:0048871	multicellular organismal homeostasis

Cellular Component

GO:0005886	plasma membrane
GO:0005925	focal adhesion

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000980 SH2 domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR006020 PTB/PI domain
IPR013625 Tensin phosphotyrosine-binding domain
IPR014020 Tensin phosphatase, C2 domain
IPR029021 Protein-tyrosine phosphatase-like
IPR029023 Tensin phosphatase, lipid phosphatase domain

PFAM