Version 5.4
Homo sapiens Gene: TRAIP
Summary
InnateDB Gene IDBG-35609.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAIP
Gene Name TRAF interacting protein
Synonyms RNF206; TRIP
Species Homo sapiens
Ensembl Gene ENSG00000183763
Encoded Proteins
IDBP-35611
TRAF interacting protein
IDBP-478731
TRAF interacting protein
IDBP-484125
TRAF interacting protein
IDBP-481070
TRAF interacting protein
IDBP-484986
TRAF interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19151749
TRAIP is a SYK antagonist in TNF signaling - overexpression of TRAIP sensitize cells to TNF-induced apoptosis.
Entrez Gene
Summary This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49828599-49856574
Strand Reverse strand
Band p21.31
Transcripts
ENST00000331456 ENSP00000328203
ENST00000491060
ENST00000473195 ENSP00000419556
ENST00000469027 ENSP00000420085
ENST00000475495
ENST00000482582 ENSP00000418544
ENST00000488860
ENST00000482243 ENSP00000419350
ENST00000477546
ENST00000489948
ENST00000473863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 39 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005057 receptor signaling protein activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005730 nucleolus
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032586
View Gene Order
ENSBTAG00000004877
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517972
RefSeq NM_005879
HUGO
OMIM
CCDS CCDS2806
HPRD 05811
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca