InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRAIP

Summary

InnateDB Protein

IDBP-35611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRAIP

Protein Name

TRAF interacting protein

Synonyms

RNF206; TRIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000328203

InnateDB Gene

IDBG-35609 (TRAIP)

Protein Structure

UniProt Annotation

Function

Inhibits activation of NF-kappa-B mediated by TNF (By similarity). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFN-beta production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation. May mediate assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN to facilitate bypass of DNA lesions and preserve genomic integrity. {ECO:0000250, ECO:0000269PubMed:22945920, ECO:0000269PubMed:24553286}.

Subcellular Localization

Cytoplasm. Cytoplasm, perinuclear region. Nucleus, nucleolus. Note=Occasionally observed at nuclear puncta.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	43 [view]
Protein-Protein	39 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0016567	protein ubiquitination
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response (InnateDB)