Homo sapiens Gene: KCNJ12
Summary
InnateDB Gene IDBG-35680.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNJ12
Gene Name potassium inwardly-rectifying channel, subfamily J, member 12
Synonyms hIRK; hIRK1; hkir2.2x; IRK-2; IRK2; kcnj12x; KCNJN1; Kir2.2; Kir2.2v;
Species Homo sapiens
Ensembl Gene ENSG00000184185
Encoded Proteins
potassium inwardly-rectifying channel, subfamily J, member 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:21376197-21419872
Strand Forward strand
Band p11.2
Transcripts
ENST00000331718 ENSP00000328150
ENST00000583088 ENSP00000463778
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005242 inward rectifier potassium channel activity
Biological Process
GO:0006813 potassium ion transport
GO:0006936 muscle contraction
GO:0007268 synaptic transmission
GO:0008016 regulation of heart contraction
GO:0034765 regulation of ion transmembrane transport
GO:0051289 protein homotetramerization
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031224 intrinsic component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Classical Kir channels pathway
Neuronal System pathway
GABA receptor activation pathway
G protein gated Potassium channels pathway
Activation of GABAB receptors pathway
Inwardly rectifying K+ channels pathway
Potassium Channels pathway
GABA B receptor activation pathway
Transmission across Chemical Synapses pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Activation of G protein gated Potassium channels pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.200629
RefSeq NM_021012 XM_005256625
HUGO
OMIM
CCDS CCDS11219
HPRD 09083
IMGT
EMBL
GenPept
RNA Seq Atlas