InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KCNJ12

Summary

InnateDB Protein

IDBP-35682.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNJ12

Protein Name

potassium inwardly-rectifying channel, subfamily J, member 12

Synonyms

hIRK; hIRK1; hkir2.2x; IRK-2; IRK2; kcnj12x; KCNJN1; Kir2.2; Kir2.2v;

Species

Homo sapiens

Ensembl Protein

ENSP00000328150

InnateDB Gene

IDBG-35680 (KCNJ12)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005242	inward rectifier potassium channel activity

Biological Process

GO:0006813	potassium ion transport
GO:0006936	muscle contraction
GO:0007268	synaptic transmission
GO:0008016	regulation of heart contraction
GO:0034765	regulation of ion transmembrane transport
GO:0051289	protein homotetramerization
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031224	intrinsic component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR003272 Potassium channel, inwardly rectifying, Kir2.2
IPR013673 Potassium channel, inwardly rectifying, Kir, N-terminal
IPR014756 Immunoglobulin E-set
IPR016449 Potassium channel, inwardly rectifying, Kir

PFAM

PF08466
PF01007

PRINTS

PR01325
PR01320

PIRSF

PIRSF005465

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt