Version 5.4
Homo sapiens Gene: WSB1
Summary
InnateDB Gene IDBG-35785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WSB1
Gene Name WD repeat and SOCS box containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109046
Encoded Proteins
IDBP-35787
WD repeat and SOCS box containing 1
IDBP-35789
WD repeat and SOCS box containing 1
IDBP-373166
WD repeat and SOCS box containing 1
IDBP-759246
IDBP-762063
IDBP-761823
IDBP-759386
IDBP-762865
IDBP-763657
IDBP-759067
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:27294076-27313631
Strand Forward strand
Band q11.1
Transcripts
ENST00000262394 ENSP00000262394
ENST00000348811 ENSP00000327055
ENST00000427287 ENSP00000416112
ENST00000467843
ENST00000487603
ENST00000578312
ENST00000583786
ENST00000583742 ENSP00000462365
ENST00000579733 ENSP00000461991
ENST00000581089
ENST00000583193 ENSP00000462595
ENST00000581440 ENSP00000462737
ENST00000584114 ENSP00000462900
ENST00000583096
ENST00000582208 ENSP00000463621
ENST00000581185 ENSP00000464109
ENST00000584354
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017677
View Gene Order
ENSBTAG00000005008
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.446017 Hs.605488 Hs.700832 Hs.713635
RefSeq NM_015626 NM_134265
HUGO
OMIM
CCDS CCDS11220 CCDS11221
HPRD 15680
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca