Version 5.4
Homo sapiens Protein: WSB1
Summary
InnateDB Protein IDBP-35787.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WSB1
Protein Name WD repeat and SOCS box containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000262394
InnateDB Gene IDBG-35785 (WSB1)
Protein Structure
UniProt Annotation
Function Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. {ECO:0000269PubMed:15601820, ECO:0000269PubMed:15965468, ECO:0000269PubMed:18093972}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0016567 protein ubiquitination
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro IPR001496 SOCS protein, C-terminal
IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF07525
PF00400
PRINTS PR00320
PIRSF
SMART SM00253
SM00969
SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Y6I7
PhosphoSite PhosphoSite-Q9Y6I7
TrEMBL A0A024QZ51
UniProt Splice Variant
Entrez Gene 26118
UniGene Hs.713635
RefSeq NP_056441
HUGO HGNC:19221
OMIM 610091
CCDS CCDS11220
HPRD 15680
IMGT
EMBL AF069313 AF072880 AF106683 AF106684 AF112205 AF240696 AL110243 AL110269 BC021110 CH471159
GenPept AAD20954 AAD28808 AAD43036 AAD43037 AAF17193 AAF82746 AAH21110 CAB53693 CAB53708 EAW51027 EAW51030

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca