Homo sapiens Gene: SOAT2
Summary
InnateDB Gene IDBG-35815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOAT2
Gene Name sterol O-acyltransferase 2
Synonyms ACACT2; ACAT2; ARGP2;
Species Homo sapiens
Ensembl Gene ENSG00000167780
Encoded Proteins
sterol O-acyltransferase 2
sterol O-acyltransferase 2
sterol O-acyltransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Summary:This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53103518-53124538
Strand Forward strand
Band q13.13
Transcripts
ENST00000301466 ENSP00000301466
ENST00000551896 ENSP00000450120
ENST00000542365 ENSP00000442234
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 2 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000062 fatty-acyl-CoA binding
GO:0004772 sterol O-acyltransferase activity
GO:0008374 O-acyltransferase activity
GO:0015485 cholesterol binding
GO:0016746 transferase activity, transferring acyl groups
GO:0034736 cholesterol O-acyltransferase activity
Biological Process
GO:0008152 metabolic process
GO:0008203 cholesterol metabolic process
GO:0010742 macrophage derived foam cell differentiation
GO:0030299 intestinal cholesterol absorption
GO:0033344 cholesterol efflux
GO:0034379 very-low-density lipoprotein particle assembly
GO:0034435 cholesterol esterification
GO:0042632 cholesterol homeostasis
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005903 brush border
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Steroid biosynthesis pathway
INOH
Steroids metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F5H7W4
UniProt Splice Variant
Entrez Gene 8435
UniGene Hs.656544
RefSeq NM_003578
HUGO HGNC:11178
OMIM 601311
CCDS CCDS8847
HPRD 03202
IMGT
EMBL AC073573
GenPept
RNA Seq Atlas 8435