Version 5.4
Homo sapiens Gene: KSR1
Summary
InnateDB Gene IDBG-35830.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KSR1
Gene Name kinase suppressor of ras 1
Synonyms KSR; RSU2
Species Homo sapiens
Ensembl Gene ENSG00000141068
Encoded Proteins
IDBP-35832
kinase suppressor of ras 1
IDBP-231723
kinase suppressor of ras 1
IDBP-231727
kinase suppressor of ras 1
IDBP-603078
kinase suppressor of ras 1
IDBP-759725
IDBP-763919
IDBP-763797
IDBP-763303
IDBP-761583
IDBP-764297
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:27456714-27626438
Strand Forward strand
Band q11.2
Transcripts
ENST00000268763 ENSP00000268763
ENST00000398988 ENSP00000381958
ENST00000398985
ENST00000398982 ENSP00000381952
ENST00000509603 ENSP00000438795
ENST00000580430 ENSP00000463790
ENST00000578981 ENSP00000463779
ENST00000583525
ENST00000579309
ENST00000581975
ENST00000580163 ENSP00000463204
ENST00000577823 ENSP00000463554
ENST00000579399
ENST00000582311
ENST00000583370 ENSP00000464081
ENST00000583998
ENST00000579961
ENST00000580822
ENST00000582410 ENSP00000464680
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005078 MAP-kinase scaffold activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007265 Ras protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043410 positive regulation of MAPK cascade
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018334
View Gene Order
ENSBTAG00000006601
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
ceramide_pathway
Ceramide signaling pathway
erbb1_downstream_pathway
ErbB1 downstream signaling
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.133534 Hs.678632 Hs.735453
RefSeq NM_014238
HUGO
OMIM
CCDS CCDS58532
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca