Homo sapiens Gene: LAMB1
Summary
InnateDB Gene IDBG-35838.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMB1
Gene Name laminin, beta 1
Synonyms CLM; LIS5;
Species Homo sapiens
Ensembl Gene ENSG00000091136
Encoded Proteins
laminin, beta 1
laminin, beta 1
laminin, beta 1
laminin, beta 1
laminin, beta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:107923799-108003255
Strand Reverse strand
Band q31.1
Transcripts
ENST00000222399 ENSP00000222399
ENST00000393561 ENSP00000377191
ENST00000393560 ENSP00000377190
ENST00000393559 ENSP00000377189
ENST00000439976 ENSP00000412686
ENST00000472714
ENST00000474380
ENST00000468518
ENST00000491196
ENST00000470995
ENST00000468999
ENST00000476039
ENST00000479448
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0005198 structural molecule activity
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0043208 glycosphingolipid binding
Biological Process
GO:0007155 cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007411 axon guidance
GO:0007566 embryo implantation
GO:0016192 vesicle-mediated transport
GO:0016477 cell migration
GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0031175 neuron projection development
GO:0034446 substrate adhesion-dependent cell spreading
GO:0042476 odontogenesis
GO:0050679 positive regulation of epithelial cell proliferation
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005606 laminin-1 complex
GO:0005607 laminin-2 complex
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0043256 laminin complex
GO:0043257 laminin-8 complex
GO:0043259 laminin-10 complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Alpha6Beta4Integrin pathway
REACTOME
Developmental Biology pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Axon guidance pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
L1CAM interactions pathway
Laminin interactions pathway
KEGG
Focal adhesion pathway
ECM-receptor interaction pathway
Toxoplasmosis pathway
Amoebiasis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Agrin in postsynaptic differentiation [Biocarta view]
PID NCI
Beta1 integrin cell surface interactions
Alpha6 beta4 integrin-ligand interactions
Beta3 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.650585
RefSeq NM_002291
HUGO
OMIM
CCDS CCDS5750
HPRD 01029
IMGT
EMBL
GenPept
RNA Seq Atlas