InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LAMB1

Summary

InnateDB Gene

IDBG-35838.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMB1

Gene Name

laminin, beta 1

Synonyms

CLM; LIS5

Species

Homo sapiens

Ensembl Gene

ENSG00000091136

Encoded Proteins

IDBP-35840

laminin, beta 1

IDBP-243362

laminin, beta 1

IDBP-243364

laminin, beta 1

IDBP-243366

laminin, beta 1

IDBP-385097

laminin, beta 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:107923799-108003255

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000222399	ENSP00000222399
ENST00000393561	ENSP00000377191
ENST00000393560	ENSP00000377190
ENST00000393559	ENSP00000377189
ENST00000439976	ENSP00000412686
ENST00000472714
ENST00000474380
ENST00000468518
ENST00000491196
ENST00000470995
ENST00000468999
ENST00000476039
ENST00000479448

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005198	structural molecule activity
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0043208	glycosphingolipid binding

Biological Process

GO:0007155	cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007411	axon guidance
GO:0007566	embryo implantation
GO:0016192	vesicle-mediated transport
GO:0016477	cell migration
GO:0021812	neuronal-glial interaction involved in cerebral cortex radial glia guided migration
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0031175	neuron projection development
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042476	odontogenesis
GO:0050679	positive regulation of epithelial cell proliferation

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005606	laminin-1 complex
GO:0005607	laminin-2 complex
GO:0005615	extracellular space
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0043256	laminin complex
GO:0043257	laminin-8 complex
GO:0043259	laminin-10 complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome