InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LAMB1

Summary

InnateDB Protein

IDBP-35840.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LAMB1

Protein Name

laminin, beta 1

Synonyms

CLM; LIS5;

Species

Homo sapiens

Ensembl Protein

ENSP00000222399

InnateDB Gene

IDBG-35838 (LAMB1)

Protein Structure

UniProt Annotation

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. {ECO:0000269PubMed:23472759}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Disease Associations

Lissencephaly 5 (LIS5) [MIM:615191]: An autosomal recessive brain malformation characterized by cobblestone changes in the cortex, more severe in the posterior region, and subcortical band heterotopia. Affected individuals have hydrocephalus, seizures, and severely delayed psychomotor development. {ECO:0000269PubMed:23472759}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	29 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005198	structural molecule activity
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0043208	glycosphingolipid binding

Biological Process

GO:0007155	cell adhesion
GO:0007162	negative regulation of cell adhesion
GO:0007411	axon guidance
GO:0007566	embryo implantation
GO:0016192	vesicle-mediated transport
GO:0016477	cell migration
GO:0021812	neuronal-glial interaction involved in cerebral cortex radial glia guided migration
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0031175	neuron projection development
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042476	odontogenesis
GO:0050679	positive regulation of epithelial cell proliferation

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005605	basal lamina
GO:0005606	laminin-1 complex
GO:0005607	laminin-2 complex
GO:0005615	extracellular space
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0043256	laminin complex
GO:0043257	laminin-8 complex
GO:0043259	laminin-10 complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR002049 EGF-like, laminin
IPR008211 Laminin, N-terminal
IPR009053 Prefoldin
IPR010989 t-SNARE
IPR013015 Laminin IV
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00008
PF00053
PF00055

PRINTS

PIRSF

SMART

SM00181
SM00180
SM00136

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P07942