Homo sapiens Gene: LGALS9
Summary
InnateDB Gene IDBG-35872.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS9
Gene Name lectin, galactoside-binding, soluble, 9
Synonyms HUAT; LGALS9A;
Species Homo sapiens
Ensembl Gene ENSG00000168961
Encoded Proteins
lectin, galactoside-binding, soluble, 9
lectin, galactoside-binding, soluble, 9
lectin, galactoside-binding, soluble, 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
LGALS9 attenuates acute lung injury by preferentially suppressing pro-inflammatory functions in pDC-like macrophages through TLR2/TLR4 down-regulation.
LGALS9 engagement impairs the cytotoxicity function and cytokine production of natural killer cells.
TLR activation promotes HAVCR2 and LGALS9 association within the same macrophage to differentially regulate IL12/IL23 expressions via STAT3 phosphorylation.
Entrez Gene
Summary The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin\'s disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:27629798-27649560
Strand Forward strand
Band q11.2
Transcripts
ENST00000302228 ENSP00000306228
ENST00000313648 ENSP00000318214
ENST00000395473 ENSP00000378856
ENST00000448970
ENST00000467111 ENSP00000462668
ENST00000481514
ENST00000486774
ENST00000579402
ENST00000584386
ENST00000584661 ENSP00000467505
ENST00000579930
ENST00000578944 ENSP00000464581
ENST00000583671
ENST00000581710 ENSP00000462382
ENST00000580779 ENSP00000463125
ENST00000577392 ENSP00000462359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005534 galactose binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007165 signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.713825 Hs.81337
RefSeq NM_002308 NM_009587 XM_006721894
HUGO
OMIM
CCDS CCDS11222 CCDS32592
HPRD 03528
IMGT
EMBL
GenPept
RNA Seq Atlas