Version 5.4
Homo sapiens Protein: LGALS9
Summary
InnateDB Protein IDBP-239467.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGALS9
Protein Name lectin, galactoside-binding, soluble, 9
Synonyms HUAT; LGALS9A;
Species Homo sapiens
Ensembl Protein ENSP00000378856
InnateDB Gene IDBG-35872 (LGALS9)
Protein Structure
UniProt Annotation
Function Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant. {ECO:0000269PubMed:16286920, ECO:0000269PubMed:18005988, ECO:0000269PubMed:18977853}.
Subcellular Localization Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}. Note=May also be secreted by a non-classical secretory pathway. {ECO:0000250}.
Disease Associations
Tissue Specificity Peripheral blood leukocytes and lymphatic tissues. Overexpressed in Hodgkin disease tissue.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005534 galactose binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007165 signal transduction
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001079 Galectin, carbohydrate recognition domain
IPR008985 Concanavalin A-like lectin/glucanases superfamily
PFAM PF00337
PRINTS
PIRSF
SMART SM00276
SM00908
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00182
PhosphoSite PhosphoSite-O00182
TrEMBL K7EPS0
UniProt Splice Variant
Entrez Gene 3965
UniGene Hs.81337
RefSeq NP_033665
HUGO HGNC:6570
OMIM 601879
CCDS CCDS11222
HPRD 03528
IMGT
EMBL AB003517 AB005894 AB006782 AB008492 AB040130 AC015688 AJ288083 AJ288084 AJ288085 AJ288086 AJ288087 AJ288088 AJ288089 AJ288090 AK223232 BC105942 BC105944 BC110340 CH471159 Z49107
GenPept AAI05943 AAI05945 AAI10341 BAA22166 BAA31542 BAB83624 BAB83625 BAD96952 BAF76327 BAF76328 CAA88922 CAB93851 EAW51037 EAW51044 EAW51045

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca