Homo sapiens Gene: TRADD
Summary
InnateDB Gene IDBG-36010.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRADD
Gene Name TNFRSF1A-associated via death domain
Synonyms Hs.89862;
Species Homo sapiens
Ensembl Gene ENSG00000102871
Encoded Proteins
TNFRSF1A-associated via death domain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
TRADD is recruited to MAVS and orchestrated complex formation with TRAF3 and TANK and with FADD and RIPK1, leading to the activation of IRF3 and NF-kappaB-TRADD is not only essential in TNFR1 signalling but also in RIG-I antiviral pathway.
Entrez Gene
Summary The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:67154180-67160298
Strand Reverse strand
Band q22.1
Transcripts
ENST00000345057 ENSP00000341268
ENST00000486556 ENSP00000462591
ENST00000566104
ENST00000563348
ENST00000566247
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 77 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0032403 protein complex binding
GO:0042802 identical protein binding
GO:0060090 binding, bridging
GO:0070513 death domain binding
Biological Process
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051291 protein heterooligomerization
GO:0051798 positive regulation of hair follicle development
GO:0097190 apoptotic signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0031264 death-inducing signaling complex
GO:0043234 protein complex
GO:0043235 receptor complex
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TNFalpha pathway
REACTOME
Extrinsic Pathway for Apoptosis pathway
Apoptosis pathway
TNF signaling pathway
Dimerization of procaspase-8 pathway
Regulation by c-FLIP pathway
Caspase-8 activation by cleavage pathway
Death Receptor Signalling pathway
KEGG
Apoptosis pathway
RIG-I-like receptor signaling pathway pathway
Adipocytokine signaling pathway pathway
Hepatitis C pathway
INOH
TNFR1 signaling pathway pathway
PID BIOCARTA
Nf-kb signaling pathway [Biocarta view]
Induction of apoptosis through dr3 and dr4/5 death receptors [Biocarta view]
Tnfr1 signaling pathway [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Tnf/stress related signaling [Biocarta view]
Sodd/tnfr1 signaling pathway [Biocarta view]
Ceramide signaling pathway [Biocarta view]
PID NCI
Ceramide signaling pathway
Caspase Cascade in Apoptosis
TNF receptor signaling pathway
TRAIL signaling pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.460996
RefSeq NM_003789 XM_005256213
HUGO
OMIM
CCDS CCDS10829
HPRD 04610
IMGT
EMBL
GenPept
RNA Seq Atlas