Bos taurus Gene: TRADD | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||
InnateDB Gene | IDBG-633302.3 | ||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
Gene Symbol | TRADD | ||||||||||||||
Gene Name | Tumor necrosis factor receptor type 1-associated DEATH domain protein | ||||||||||||||
Synonyms | |||||||||||||||
Species | Bos taurus | ||||||||||||||
Ensembl Gene | ENSBTAG00000012642 | ||||||||||||||
Encoded Proteins |
Tumor necrosis factor receptor type 1-associated DEATH domain protein
|
||||||||||||||
Protein Structure | |||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||
Summary |
[Homo sapiens] TRADD is recruited to MAVS and orchestrated complex formation with TRAF3 and TANK and with FADD and RIPK1, leading to the activation of IRF3 and NF-kappaB-TRADD is not only essential in TNFR1 signalling but also in RIG-I antiviral pathway.
|
||||||||||||||
Entrez Gene | |||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102871:
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008] |
||||||||||||||
Gene Information | |||||||||||||||
Type | Protein coding | ||||||||||||||
Genomic Location | Chromosome 18:34912745-34918691 | ||||||||||||||
Strand | Reverse strand | ||||||||||||||
Band | |||||||||||||||
Transcripts |
|
||||||||||||||
Interactions | |||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.
|
||||||||||||||
Gene Ontology | |||||||||||||||
Molecular Function |
|
||||||||||||||
Biological Process |
|
||||||||||||||
Cellular Component |
|
||||||||||||||
Orthologs | |||||||||||||||
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||||||||||
Pathways | |||||||||||||||
NETPATH | |||||||||||||||
REACTOME |
Extrinsic Pathway for Apoptosis pathway
TNF signaling pathway
Caspase-8 activation by cleavage pathway
Dimerization of procaspase-8 pathway
Death Receptor Signalling pathway
Regulation by c-FLIP pathway
Apoptosis pathway
|
||||||||||||||
KEGG | |||||||||||||||
INOH | |||||||||||||||
PID NCI | |||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||
NETPATH |
TNFalpha pathway
|
||||||||||||||
REACTOME |
Dimerization of procaspase-8 pathway
Caspase-8 activation by cleavage pathway
TNF signaling pathway
Extrinsic Pathway for Apoptosis pathway
Apoptosis pathway
Regulation by c-FLIP pathway
Death Receptor Signalling pathway
Apoptosis pathway
Dimerization of procaspase-8 pathway
TNF signaling pathway
Caspase-8 activation by cleavage pathway
Death Receptor Signalling pathway
Regulation by c-FLIP pathway
Extrinsic Pathway for Apoptosis pathway
|
||||||||||||||
KEGG |
Apoptosis pathway
Adipocytokine signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Hepatitis C pathway
Adipocytokine signaling pathway pathway
Apoptosis pathway
RIG-I-like receptor signaling pathway pathway
Hepatitis C pathway
|
||||||||||||||
INOH |
TNFR1 signaling pathway pathway
|
||||||||||||||
PID NCI |
Ceramide signaling pathway
Caspase Cascade in Apoptosis
TNF receptor signaling pathway
TRAIL signaling pathway
HIV-1 Nef: Negative effector of Fas and TNF-alpha
|
||||||||||||||
Cross-References | |||||||||||||||
SwissProt | |||||||||||||||
TrEMBL | |||||||||||||||
UniProt Splice Variant | |||||||||||||||
Entrez Gene | |||||||||||||||
UniGene | Bt.15875 | ||||||||||||||
RefSeq | NM_001045896 | ||||||||||||||
HUGO | |||||||||||||||
OMIM | |||||||||||||||
CCDS | |||||||||||||||
HPRD | |||||||||||||||
IMGT | |||||||||||||||
EMBL | |||||||||||||||
GenPept | |||||||||||||||
RNA Seq Atlas | |||||||||||||||