Homo sapiens Gene: MYO9B
Summary
InnateDB Gene IDBG-36042.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYO9B
Gene Name myosin IXB
Synonyms CELIAC4; MYR5;
Species Homo sapiens
Ensembl Gene ENSG00000099331
Encoded Proteins
myosin IXB
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:17075781-17214537
Strand Forward strand
Band p13.11
Transcripts
ENST00000397274 ENSP00000380444
ENST00000597572
ENST00000598101
ENST00000601749
ENST00000598419 ENSP00000472296
ENST00000593533
ENST00000598464
ENST00000599420
ENST00000593411
ENST00000596942 ENSP00000472964
ENST00000601490
ENST00000595641 ENSP00000472915
ENST00000602177 ENSP00000472611
ENST00000602158 ENSP00000469437
ENST00000595618 ENSP00000471457
ENST00000597881
ENST00000597073 ENSP00000469289
ENST00000594824 ENSP00000471367
ENST00000594971 ENSP00000470849
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000146 microfilament motor activity
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005096 GTPase activator activity
GO:0005100 Rho GTPase activator activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016887 ATPase activity
GO:0030898 actin-dependent ATPase activity
GO:0043008 ATP-dependent protein binding
GO:0043531 ADP binding
GO:0046872 metal ion binding
GO:0051015 actin filament binding
Biological Process
GO:0002548 monocyte chemotaxis
GO:0006200 ATP catabolic process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0008152 metabolic process
GO:0030010 establishment of cell polarity
GO:0030048 actin filament-based movement
GO:0032321 positive regulation of Rho GTPase activity
GO:0035556 intracellular signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0048246 macrophage chemotaxis
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0072673 lamellipodium morphogenesis
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016459 myosin complex
GO:0030027 lamellipodium
GO:0031941 filamentous actin
GO:0032433 filopodium tip
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Signaling by Rho GTPases pathway
Innate Immune System pathway
Signal Transduction pathway
Immune System pathway
Rho GTPase cycle pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.123198
RefSeq NM_001130065 NM_004145 XM_005259915 XM_006722755 XM_006722756 XM_006722757 XM_006722758
HUGO
OMIM
CCDS CCDS46010
HPRD 03677
IMGT
EMBL
GenPept
RNA Seq Atlas