Homo sapiens Gene: TCF4 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-3611.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | TCF4 | ||||||||||||||||||||||||||||
Gene Name | transcription factor 4 | ||||||||||||||||||||||||||||
Synonyms | bHLHb19; E2-2; ITF-2; ITF2; PTHS; SEF-2; SEF2; SEF2-1; SEF2-1A; SEF2-1B; SEF2-1D; TCF-4 | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000196628 | ||||||||||||||||||||||||||||
Encoded Proteins |
transcription factor 4
transcription factor 4
transcription factor 4
transcription factor 4
transcription factor 4
transcription factor 4
transcription factor 4
transcription factor 4
transcription factor 4
transcription factor 4
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||
Summary |
Transcription Factor that is an essential and specific regulator of Plasmacytoid dendritic cell development
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Entrez Gene | |||||||||||||||||||||||||||||
Summary |
This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011] This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box (\'E-box\') binding site (\'CANNTG\') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq, Aug 2011] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 18:55222331-55664787 | ||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||
Band | q21.2 | ||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
ID pathway
TGF_beta_Receptor pathway
Wnt pathway
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REACTOME |
CDO in myogenesis pathway
Developmental Biology pathway
Myogenesis pathway
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KEGG | |||||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||||
PID NCI |
Coregulation of Androgen receptor activity
Regulation of nuclear beta catenin signaling and target gene transcription
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Cross-References | |||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
UniGene | Hs.599356 Hs.605153 Hs.606264 Hs.624776 Hs.719509 Hs.742885 | ||||||||||||||||||||||||||||
RefSeq | NM_001083962 NM_001243226 NM_001243227 NM_001243228 NM_001243230 NM_001243231 NM_001243232 NM_001243233 NM_001243234 NM_001243235 NM_001243236 NM_003199 XM_005266739 XM_005266741 XM_005266743 XM_005266744 XM_005266745 XM_005266746 XM_005266747 XM_005266749 XM_005266750 XM_005266752 XM_005266754 XM_005266755 XM_006722530 XM_006722531 XM_006722532 XM_006722533 XM_006722534 XM_006722536 XM_006722537 XM_006722538 XM_006722539 XM_006722540 | ||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS11960 CCDS42438 CCDS58623 CCDS58624 CCDS58625 CCDS58626 CCDS58627 CCDS58628 CCDS58629 CCDS58630 CCDS58631 CCDS59321 | ||||||||||||||||||||||||||||
HPRD | 03780 | ||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||