|Homo sapiens Gene: OLFM4|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||olfactomedin 4|
|Synonyms||bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD; OLM4; UNQ362;|
|Useful resources||Stemformatics EHFPI ImmGen|
OLFM4 exerts considerable influence on the host defence against H. pylori infection acting through NOD1 and NOD2 mediated NF-kappaB activation and subsequent cytokines and chemokines production, which in turn inhibit host immune response and contribute to persistence of H. pylori colonization.
OLFM4 is a negative regulator of neutrophil bactericidal activity by restricting cathepsin C-mediated protease activities. (Demonstrated in mice)
|InnateDB Annotation from Orthologs|
[Mus musculus] Olfm4 is a negative regulator of neutrophil bactericidal activity by restricting cathepsin C-mediated protease activities.
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
|Genomic Location||Chromosome 13:53028759-53052057|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
|UniProt Splice Variant|
|EMBL||AF097021 AL390736 AY358567 BC047740 BC117329 CH471124|
|GenPept||AAC72970 AAH47740 AAI17330 AAQ88930 CAH71311 EAW52052 EAW52053|
|RNA Seq Atlas||10562|