Homo sapiens Gene: OLFM4
Summary
InnateDB Gene IDBG-36123.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OLFM4
Gene Name olfactomedin 4
Synonyms bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD; OLM4; UNQ362;
Species Homo sapiens
Ensembl Gene ENSG00000102837
Encoded Proteins
olfactomedin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
OLFM4 exerts considerable influence on the host defence against H. pylori infection acting through NOD1 and NOD2 mediated NF-kappaB activation and subsequent cytokines and chemokines production, which in turn inhibit host immune response and contribute to persistence of H. pylori colonization.
OLFM4 is a negative regulator of neutrophil bactericidal activity by restricting cathepsin C-mediated protease activities. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Olfm4 is a negative regulator of neutrophil bactericidal activity by restricting cathepsin C-mediated protease activities.
Entrez Gene
Summary This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:53028759-53052057
Strand Forward strand
Band q14.3
Transcripts
ENST00000219022 ENSP00000219022
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0045296 cadherin binding
Biological Process
GO:0007155 cell adhesion
GO:0008152 metabolic process
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0050777 negative regulation of immune response
GO:0051260 protein homooligomerization
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0042581 specific granule
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q6UX06
TrEMBL A0A024QZ95
UniProt Splice Variant
Entrez Gene 10562
UniGene Hs.508113 Hs.714531
RefSeq NM_006418
HUGO HGNC:17190
OMIM 614061
CCDS CCDS9440
HPRD
IMGT
EMBL AF097021 AL390736 AY358567 BC047740 BC117329 CH471124
GenPept AAC72970 AAH47740 AAI17330 AAQ88930 CAH71311 EAW52052 EAW52053
RNA Seq Atlas 10562