InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: OLFM4

Summary

InnateDB Gene

IDBG-36123.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OLFM4

Gene Name

olfactomedin 4

Synonyms

bA209J19.1; GC1; GW112; hGC-1; hOLfD; OlfD; OLM4; UNQ362

Species

Homo sapiens

Ensembl Gene

ENSG00000102837

Encoded Proteins

IDBP-36127

olfactomedin 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20534456

OLFM4 exerts considerable influence on the host defence against H. pylori infection acting through NOD1 and NOD2 mediated NF-kappaB activation and subsequent cytokines and chemokines production, which in turn inhibit host immune response and contribute to persistence of H. pylori colonization.

PMID 22844115

OLFM4 is a negative regulator of neutrophil bactericidal activity by restricting cathepsin C-mediated protease activities. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 22844115

[Mus musculus] Olfm4 is a negative regulator of neutrophil bactericidal activity by restricting cathepsin C-mediated protease activities.

Entrez Gene

Summary

This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:53028759-53052057

Strand

Forward strand

Band

q14.3

Transcripts

ENST00000219022

ENSP00000219022

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0045296	cadherin binding

Biological Process

GO:0007155	cell adhesion
GO:0008152	metabolic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0050777	negative regulation of immune response
GO:0051260	protein homooligomerization
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0042581	specific granule
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022026

View Gene Order

ENSBTAG00000022779

Not yet available

Cross-References

SwissProt

Q6UX06

TrEMBL

A0A024QZ95

UniProt Splice Variant

Entrez Gene

10562

UniGene

Hs.508113 Hs.714531

RefSeq

NM_006418

HUGO

HGNC:17190

OMIM

614061

CCDS

CCDS9440

HPRD

IMGT

EMBL

AF097021 AL390736 AY358567 BC047740 BC117329 CH471124

GenPept

AAC72970 AAH47740 AAI17330 AAQ88930 CAH71311 EAW52052 EAW52053

RNA Seq Atlas

10562