Version 5.4
Homo sapiens Gene: ANXA5
Summary
InnateDB Gene IDBG-36172.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANXA5
Gene Name annexin A5
Synonyms ANX5; ENX2; HEL-S-7; PP4; RPRGL3
Species Homo sapiens
Ensembl Gene ENSG00000164111
Encoded Proteins
IDBP-36174
annexin A5
IDBP-483478
annexin A5
IDBP-477527
annexin A5
IDBP-475555
annexin A5
IDBP-485160
annexin A5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:121667955-121697113
Strand Reverse strand
Band q27
Transcripts
ENST00000296511 ENSP00000296511
ENST00000501272 ENSP00000424106
ENST00000506395 ENSP00000421421
ENST00000515017 ENSP00000424199
ENST00000509648
ENST00000515717
ENST00000511552
ENST00000509016
ENST00000513428
ENST00000513523
ENST00000513728 ENSP00000427135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated
Total 39 [view]
Protein-Protein 38 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004859 phospholipase inhibitor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
Biological Process
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0010033 response to organic substance
GO:0043066 negative regulation of apoptotic process
GO:0043086 negative regulation of catalytic activity
GO:0050819 negative regulation of coagulation
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
GO:0072563 endothelial microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027712
View Gene Order
ENSBTAG00000021746
Not yet available
Cross-References
SwissProt
TrEMBL D6RBE9
UniProt Splice Variant
Entrez Gene 308
UniGene Hs.480653 Hs.611925 Hs.715689
RefSeq NM_001154
HUGO HGNC:543
OMIM 131230
CCDS CCDS3720
HPRD 00568
IMGT
EMBL AC096730
GenPept
RNA Seq Atlas 308

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca