InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ANXA5

Summary

InnateDB Protein

IDBP-36174.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA5

Protein Name

annexin A5

Synonyms

ANX5; ENX2; HEL-S-7; PP4; RPRGL3;

Species

Homo sapiens

Ensembl Protein

ENSP00000296511

InnateDB Gene

IDBG-36172 (ANXA5)

Protein Structure

UniProt Annotation

Function

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Subcellular Localization

Disease Associations

Pregnancy loss, recurrent, 3 (RPRGL3) [MIM:614391]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. {ECO:0000269PubMed:17339269}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004859	phospholipase inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0005544	calcium-dependent phospholipid binding

Biological Process

GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0010033	response to organic substance
GO:0043066	negative regulation of apoptotic process
GO:0043086	negative regulation of catalytic activity
GO:0050819	negative regulation of coagulation

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome
GO:0072563	endothelial microparticle