InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HYAL1

Summary

InnateDB Gene

IDBG-36447.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HYAL1

Gene Name

hyaluronoglucosaminidase 1

Synonyms

HYAL-1; LUCA1; NAT6;

Species

Homo sapiens

Ensembl Gene

ENSG00000114378

Encoded Proteins

IDBP-36449

hyaluronoglucosaminidase 1

IDBP-36451

hyaluronoglucosaminidase 1

IDBP-240159

hyaluronoglucosaminidase 1

IDBP-240161

hyaluronoglucosaminidase 1

IDBP-378213

hyaluronoglucosaminidase 1

IDBP-378214

hyaluronoglucosaminidase 1

IDBP-378218

hyaluronoglucosaminidase 1

IDBP-378219

hyaluronoglucosaminidase 1

IDBP-808187

hyaluronoglucosaminidase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:50299889-50312381

Strand

Reverse strand

Band

p21.31

Transcripts

ENST00000266031	ENSP00000266031
ENST00000320295	ENSP00000346068
ENST00000395144	ENSP00000378576
ENST00000395143	ENSP00000378575
ENST00000447605	ENSP00000390149
ENST00000457214	ENSP00000393358
ENST00000418723	ENSP00000394526
ENST00000452672	ENSP00000391666
ENST00000618175	ENSP00000477903

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004415	hyalurononglucosaminidase activity
GO:0008134	transcription factor binding
GO:0050501	hyaluronan synthase activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0005975	carbohydrate metabolic process
GO:0006954	inflammatory response
GO:0009615	response to virus
GO:0010634	positive regulation of epithelial cell migration
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030212	hyaluronan metabolic process
GO:0030213	hyaluronan biosynthetic process
GO:0030214	hyaluronan catabolic process
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0036120	cellular response to platelet-derived growth factor stimulus
GO:0044281	small molecule metabolic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0045927	positive regulation of growth
GO:0046677	response to antibiotic
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051216	cartilage development
GO:0060272	embryonic skeletal joint morphogenesis
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071467	cellular response to pH
GO:0071493	cellular response to UV-B
GO:1900106	positive regulation of hyaluranon cable assembly

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0031410	cytoplasmic vesicle
GO:0036117	hyaluranon cable
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome