InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HYAL1

Summary

InnateDB Protein

IDBP-36451.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HYAL1

Protein Name

hyaluronoglucosaminidase 1

Synonyms

HYAL-1; LUCA1; NAT6;

Species

Homo sapiens

Ensembl Protein

ENSP00000346068

InnateDB Gene

IDBG-36447 (HYAL1)

Protein Structure

UniProt Annotation

Function

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. {ECO:0000269PubMed:12084718}.

Subcellular Localization

Secreted {ECO:0000269PubMed:9223416}. Lysosome {ECO:0000269PubMed:9223416}.

Disease Associations

Mucopolysaccharidosis 9 (MPS9) [MIM:601492]: A lysosomal storage disease characterized by high hyaluronan concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. {ECO:0000269PubMed:10339581}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues. {ECO:0000269PubMed:10339581, ECO:0000269PubMed:12084718, ECO:0000269PubMed:9223416}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004415	hyalurononglucosaminidase activity
GO:0008134	transcription factor binding
GO:0050501	hyaluronan synthase activity

Biological Process

GO:0000302	response to reactive oxygen species
GO:0005975	carbohydrate metabolic process
GO:0006954	inflammatory response
GO:0009615	response to virus
GO:0010634	positive regulation of epithelial cell migration
GO:0030203	glycosaminoglycan metabolic process
GO:0030204	chondroitin sulfate metabolic process
GO:0030207	chondroitin sulfate catabolic process
GO:0030212	hyaluronan metabolic process
GO:0030213	hyaluronan biosynthetic process
GO:0030214	hyaluronan catabolic process
GO:0030307	positive regulation of cell growth
GO:0030308	negative regulation of cell growth
GO:0036120	cellular response to platelet-derived growth factor stimulus
GO:0044281	small molecule metabolic process
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0045766	positive regulation of angiogenesis
GO:0045785	positive regulation of cell adhesion
GO:0045927	positive regulation of growth
GO:0046677	response to antibiotic
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051216	cartilage development
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071467	cellular response to pH
GO:0071493	cellular response to UV-B
GO:1900106	positive regulation of hyaluranon cable assembly

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0031410	cytoplasmic vesicle
GO:0036117	hyaluranon cable
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome