Homo sapiens Gene: TRPC3
Summary
InnateDB Gene IDBG-36538.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPC3
Gene Name transient receptor potential cation channel, subfamily C, member 3
Synonyms TRP3;
Species Homo sapiens
Ensembl Gene ENSG00000138741
Encoded Proteins
transient receptor potential cation channel, subfamily C, member 3
transient receptor potential cation channel, subfamily C, member 3
transient receptor potential cation channel, subfamily C, member 3
transient receptor potential cation channel, subfamily C, member 3
transient receptor potential cation channel, subfamily C, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:121879027-121951754
Strand Reverse strand
Band q27
Transcripts
ENST00000379645 ENSP00000368966
ENST00000264811 ENSP00000264811
ENST00000506449 ENSP00000423866
ENST00000513531 ENSP00000426899
ENST00000502968 ENSP00000422214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005488 binding
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0007602 phototransduction
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0030168 platelet activation
GO:0033198 response to ATP
GO:0034220 ion transmembrane transport
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Developmental Biology pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Platelet calcium homeostasis pathway
Signaling by GPCR pathway
Stimuli-sensing channels pathway
Platelet activation, signaling and aggregation pathway
Axon guidance pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Netrin-1 signaling pathway
Role of second messengers in netrin-1 signaling pathway
Platelet homeostasis pathway
Ion channel transport pathway
Elevation of cytosolic Ca2+ levels pathway
Effects of PIP2 hydrolysis pathway
TRP channels pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
Ion channels and their functional role in vascular endothelium [Biocarta view]
PID NCI
Trk receptor signaling mediated by PI3K and PLC-gamma
Cross-References
SwissProt Q13507
TrEMBL D6R902 Q4W5P7
UniProt Splice Variant
Entrez Gene 7222
UniGene Hs.150981 Hs.629907
RefSeq NM_003305 XM_006714296 NM_001130698
HUGO HGNC:12335
OMIM 602345
CCDS CCDS3725 CCDS47130
HPRD 15999
IMGT
EMBL AB255424 AC079341 AC108930 AY865574 BC093682 BC093684 U47050 X89068 Y13758
GenPept AAC51653 AAH93682 AAH93684 AAW62292 AAY40971 BAF76424 CAA61448 CAA74083
RNA Seq Atlas 7222