InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRPC3

Summary

InnateDB Protein

IDBP-36540.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPC3

Protein Name

transient receptor potential cation channel, subfamily C, member 3

Synonyms

TRP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000368966

InnateDB Gene

IDBG-36538 (TRPC3)

Protein Structure

UniProt Annotation

Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5- triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. {ECO:0000269PubMed:20095964, ECO:0000269PubMed:8646775, ECO:0000269PubMed:9417057, ECO:0000269PubMed:9930701}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005488	binding
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0007602	phototransduction
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0030168	platelet activation
GO:0033198	response to ATP
GO:0034220	ion transmembrane transport
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR002153 Transient receptor potential channel, canonical
IPR004729 Transient receptor potential channel
IPR005459 Transient receptor potential channel, canonical 3
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR013555 Transient receptor ion channel domain
IPR016024 Armadillo-type fold
IPR020683 Ankyrin repeat-containing domain

PFAM