Version 5.4
Homo sapiens Gene: NUDT6
Summary
InnateDB Gene IDBG-37109.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUDT6
Gene Name nudix (nucleoside diphosphate linked moiety X)-type motif 6
Synonyms ASFGF2; FGF-AS; FGF2AS; GFG-1; GFG1
Species Homo sapiens
Ensembl Gene ENSG00000170917
Encoded Proteins
IDBP-37111
nudix (nucleoside diphosphate linked moiety X)-type motif 6
IDBP-37113
nudix (nucleoside diphosphate linked moiety X)-type motif 6
IDBP-477284
nudix (nucleoside diphosphate linked moiety X)-type motif 6
IDBP-483017
nudix (nucleoside diphosphate linked moiety X)-type motif 6
IDBP-474034
nudix (nucleoside diphosphate linked moiety X)-type motif 6
IDBP-475962
nudix (nucleoside diphosphate linked moiety X)-type motif 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:122888697-122922968
Strand Reverse strand
Band q28.1
Transcripts
ENST00000339154 ENSP00000344011
ENST00000304430 ENSP00000306070
ENST00000512116 ENSP00000420843
ENST00000503370 ENSP00000422698
ENST00000510735 ENSP00000423745
ENST00000502270 ENSP00000424117
ENST00000513517
ENST00000608639
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 2 [view]
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008083 growth factor activity
GO:0016787 hydrolase activity
Biological Process
GO:0008150 biological_process
GO:0008152 metabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050174
View Gene Order
ENSBTAG00000005695
Not yet available
Cross-References
SwissProt
TrEMBL E9PBZ9 Q59EQ3
UniProt Splice Variant
Entrez Gene 11162
UniGene
RefSeq NM_007083 NM_198041
HUGO HGNC:8053
OMIM 606261
CCDS CCDS3729 CCDS43268
HPRD 05880
IMGT
EMBL AB209758 AC021205
GenPept BAD92995
RNA Seq Atlas 11162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca