|Homo sapiens Gene: DOCK3|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||dedicator of cytokinesis 3|
dedicator of cytokinesis 3
|Useful resources||Stemformatics EHFPI ImmGen|
This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
|Genomic Location||Chromosome 3:50675241-51384198|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Factors involved in megakaryocyte development and platelet production pathway
Integrin signaling pathway pathway
|UniProt Splice Variant|
|EMBL||AB002297 AY145303 AY254099|
|GenPept||AAN12301 AAP80572 BAA20759|
|RNA Seq Atlas||1795|