Version 5.4
| Bos taurus Gene: DOCK3 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-645771.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | DOCK3 | ||||||||
| Gene Name | Uncharacterized protein | ||||||||
| Synonyms | DOCK3 | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000001874 | ||||||||
| Encoded Proteins |
dedicator of cytokinesis 3
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000088538:
This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 22:49953523-50134786 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
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| KEGG | |||||||||
| INOH |
Integrin signaling pathway pathway
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| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | E1B7E2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 524692 | ||||||||
| UniGene | |||||||||
| RefSeq | XM_002697072 XM_003585354 | ||||||||
| HUGO | HGNC:2989 | ||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DAAA02054396 DAAA02054397 DAAA02054398 DAAA02054399 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 524692 | ||||||||