Version 5.4
Homo sapiens Gene: BAI1
Summary
InnateDB Gene IDBG-37582.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAI1
Gene Name brain-specific angiogenesis inhibitor 1
Synonyms GDAIF
Species Homo sapiens
Ensembl Gene ENSG00000181790
Encoded Proteins
IDBP-37584
brain-specific angiogenesis inhibitor 1
IDBP-483699
brain-specific angiogenesis inhibitor 1
IDBP-482490
brain-specific angiogenesis inhibitor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one \'functional\' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:142449430-142545009
Strand Forward strand
Band q24.3
Transcripts
ENST00000323289 ENSP00000313046
ENST00000517894 ENSP00000430945
ENST00000521208 ENSP00000427783
ENST00000518820
ENST00000518812
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007409 axonogenesis
GO:0007422 peripheral nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0016525 negative regulation of angiogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034730
View Gene Order
ENSBTAG00000006385
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt O14514
TrEMBL
UniProt Splice Variant
Entrez Gene 575
UniGene Hs.194654
RefSeq NM_001702 XM_005251015
HUGO HGNC:943
OMIM 602682
CCDS CCDS64985
HPRD 04062
IMGT
EMBL AB005297 AC139676
GenPept BAA23647
RNA Seq Atlas 575

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca