Version 5.4
Homo sapiens Gene: COPZ1
Summary
InnateDB Gene IDBG-37816.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COPZ1
Gene Name coatomer protein complex, subunit zeta 1
Synonyms COPZ; HSPC181; zeta-COP; zeta1-COP
Species Homo sapiens
Ensembl Gene ENSG00000111481
Encoded Proteins
IDBP-37818
coatomer protein complex, subunit zeta 1
IDBP-376861
coatomer protein complex, subunit zeta 1
IDBP-587173
coatomer protein complex, subunit zeta 1
IDBP-589036
coatomer protein complex, subunit zeta 1
IDBP-589234
coatomer protein complex, subunit zeta 1
IDBP-591815
coatomer protein complex, subunit zeta 1
IDBP-584363
coatomer protein complex, subunit zeta 1
IDBP-602751
coatomer protein complex, subunit zeta 1
IDBP-591963
coatomer protein complex, subunit zeta 1
IDBP-598141
coatomer protein complex, subunit zeta 1
IDBP-587488
coatomer protein complex, subunit zeta 1
IDBP-595506
coatomer protein complex, subunit zeta 1
IDBP-603716
coatomer protein complex, subunit zeta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:54301202-54351849
Strand Forward strand
Band q13.13
Transcripts
ENST00000262061 ENSP00000262061
ENST00000455864 ENSP00000410620
ENST00000552848 ENSP00000449414
ENST00000548076
ENST00000553009
ENST00000549043 ENSP00000449270
ENST00000551962 ENSP00000447100
ENST00000552218 ENSP00000449341
ENST00000551412
ENST00000550027
ENST00000553231 ENSP00000448997
ENST00000552362 ENSP00000448444
ENST00000550171 ENSP00000448005
ENST00000549116 ENSP00000448235
ENST00000551779 ENSP00000449108
ENST00000548281
ENST00000548753 ENSP00000448945
ENST00000550713 ENSP00000449072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 28 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0048205 COPI coating of Golgi vesicle
GO:0061024 membrane organization
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0030117 membrane coat
GO:0030126 COPI vesicle coat
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000060992
View Gene Order
ENSBTAG00000005384
Not yet available
Pathways
NETPATH
REACTOME
REACT_11096
COPI Mediated Transport pathway
REACT_11208
Golgi to ER Retrograde Transport pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.505652
RefSeq NM_001271734 NM_001271735 NM_001271736 NM_016057
HUGO
OMIM
CCDS CCDS61137 CCDS61138 CCDS61139 CCDS8877
HPRD 16738
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca