Homo sapiens Gene: PDE4C
Summary
InnateDB Gene IDBG-37833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE4C
Gene Name phosphodiesterase 4C, cAMP-specific
Synonyms DPDE1
Species Homo sapiens
Ensembl Gene ENSG00000105650
Encoded Proteins
phosphodiesterase 4C, cAMP-specific
phosphodiesterase 4C, cAMP-specific
phosphodiesterase 4C, cAMP-specific
phosphodiesterase 4C, cAMP-specific
phosphodiesterase 4C, cAMP-specific
phosphodiesterase 4C, cAMP-specific
phosphodiesterase 4C, cAMP-specific
phosphodiesterase 4C, cAMP-specific
phosphodiesterase 4C, cAMP-specific
phosphodiesterase 4C, cAMP-specific
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:18207961-18255419
Strand Reverse strand
Band p13.11
Transcripts
ENST00000355502 ENSP00000347689
ENST00000262805 ENSP00000262805
ENST00000447275 ENSP00000402091
ENST00000539010 ENSP00000439470
ENST00000594465 ENSP00000470210
ENST00000594617 ENSP00000469696
ENST00000599754 ENSP00000472034
ENST00000593594 ENSP00000474849
ENST00000598111 ENSP00000474591
ENST00000595343 ENSP00000473937
ENST00000599188 ENSP00000473713
ENST00000600667
ENST00000597297 ENSP00000476923
ENST00000596647
ENST00000597573
ENST00000597360
ENST00000610023 ENSP00000476961
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0046872 metal ion binding
Biological Process
GO:0006198 cAMP catabolic process
GO:0007165 signal transduction
GO:0008152 metabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0072372 primary cilium
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
DARPP-32 events pathway
Opioid Signalling pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
KEGG
Purine metabolism pathway
INOH
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.132584 Hs.710873
RefSeq NM_000923 NM_001098818 NM_001098819
HUGO
OMIM
CCDS CCDS12373 CCDS42523 CCDS46016
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas