InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE4C

Summary

InnateDB Protein

IDBP-375909.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE4C

Protein Name

phosphodiesterase 4C, cAMP-specific

Synonyms

DPDE1;

Species

Homo sapiens

Ensembl Protein

ENSP00000402091

InnateDB Gene

IDBG-37833 (PDE4C)

Protein Structure

UniProt Annotation

Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. {ECO:0000269PubMed:17727341}.

Subcellular Localization

Cell projection, cilium {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in various tissues but not in cells of the immune system.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	2 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0046872	metal ion binding

Biological Process

GO:0006198	cAMP catabolic process
GO:0007165	signal transduction
GO:0008152	metabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005829	cytosol
GO:0072372	primary cilium

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt