Homo sapiens Gene: GDF15
Summary
InnateDB Gene IDBG-38078.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GDF15
Gene Name growth differentiation factor 15
Synonyms GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB;
Species Homo sapiens
Ensembl Gene ENSG00000130513
Encoded Proteins
growth differentiation factor 15
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:18374731-18389176
Strand Forward strand
Band p13.11
Transcripts
ENST00000252809 ENSP00000252809
ENST00000597765 ENSP00000469819
ENST00000594925
ENST00000595973 ENSP00000470531
ENST00000604609
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 4 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0008083 growth factor activity
Biological Process
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007267 cell-cell signaling
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Direct p53 effectors
p73 transcription factor network
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.722195
RefSeq NM_004864
HUGO
OMIM
CCDS CCDS12376
HPRD 05608
IMGT
EMBL
GenPept
RNA Seq Atlas