InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GDF15

Summary

InnateDB Protein

IDBP-38080.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GDF15

Protein Name

growth differentiation factor 15

Synonyms

GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB;

Species

Homo sapiens

Ensembl Protein

ENSP00000252809

InnateDB Gene

IDBG-38078 (GDF15)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	4 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0008083	growth factor activity

Biological Process

GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007267	cell-cell signaling

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001839 Transforming growth factor-beta, C-terminal
IPR029034 Cystine-knot cytokine

PFAM

PF00019

PRINTS

PIRSF

SMART

SM00204

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99988

PhosphoSite

PhosphoSite-Q99988

TrEMBL

UniProt Splice Variant

Entrez Gene

9518

UniGene

Hs.722195

RefSeq

NP_004855

HUGO

HGNC:30142

OMIM

605312

CCDS

CCDS12376

HPRD

05608

IMGT

EMBL

AB000584 AC008397 AF003934 AF008303 AF019770 AF173860 AK291530 BC000529 BC008962 BT019465 CH471106 U88323

GenPept

AAB88673 AAB88913 AAC24456 AAC39537 AAF89834 AAH00529 AAH08962 AAV38272 BAA19151 BAF84219 EAW84694