Version 5.4
Homo sapiens Gene: EIF3M
Summary
InnateDB Gene IDBG-38246.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3M
Gene Name eukaryotic translation initiation factor 3, subunit M
Synonyms B5; hfl-B5; PCID1; TANGO7
Species Homo sapiens
Ensembl Gene ENSG00000149100
Encoded Proteins
IDBP-38248
eukaryotic translation initiation factor 3, subunit M
IDBP-591988
eukaryotic translation initiation factor 3, subunit M
IDBP-592548
eukaryotic translation initiation factor 3, subunit M
IDBP-602293
eukaryotic translation initiation factor 3, subunit M
IDBP-590483
eukaryotic translation initiation factor 3, subunit M
IDBP-585736
eukaryotic translation initiation factor 3, subunit M
IDBP-597920
eukaryotic translation initiation factor 3, subunit M
IDBP-595758
eukaryotic translation initiation factor 3, subunit M
IDBP-598937
eukaryotic translation initiation factor 3, subunit M
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:32583798-32606262
Strand Forward strand
Band p13
Transcripts
ENST00000323213 ENSP00000319910
ENST00000531921 ENSP00000435501
ENST00000531120 ENSP00000436049
ENST00000531186
ENST00000525782 ENSP00000434080
ENST00000524896 ENSP00000436787
ENST00000532444 ENSP00000435834
ENST00000524711 ENSP00000432286
ENST00000530026
ENST00000532054
ENST00000533439 ENSP00000432891
ENST00000526267 ENSP00000432139
ENST00000525054
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
Experimentally validated
Total 48 [view]
Protein-Protein 48 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0002183 cytoplasmic translational initiation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
Cellular Component
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027170
View Gene Order
ENSBTAG00000005338
Not yet available
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PSB3
UniProt Splice Variant
Entrez Gene 10480
UniGene Hs.502244 Hs.635554 Hs.642454 Hs.654746 Hs.685481
RefSeq NM_006360
HUGO HGNC:24460
OMIM 609641
CCDS CCDS7880
HPRD 09969
IMGT
EMBL AL078477
GenPept
RNA Seq Atlas 10480

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca