InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: WNT16

Summary

InnateDB Gene

IDBG-38278.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WNT16

Gene Name

wingless-type MMTV integration site family, member 16

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000002745

Encoded Proteins

IDBP-38282

wingless-type MMTV integration site family, member 16

IDBP-38284

wingless-type MMTV integration site family, member 16

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:121325367-121341104

Strand

Forward strand

Band

q31.31

Transcripts

ENST00000361301	ENSP00000355065
ENST00000222462	ENSP00000222462

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0003408	optic cup formation involved in camera-type eye development
GO:0007275	multicellular organismal development
GO:0010628	positive regulation of gene expression
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030216	keratinocyte differentiation
GO:0043616	keratinocyte proliferation
GO:0045165	cell fate commitment
GO:0046330	positive regulation of JNK cascade
GO:0046849	bone remodeling
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0060548	negative regulation of cell death
GO:0090399	replicative senescence
GO:0090403	oxidative stress-induced premature senescence