Homo sapiens Gene: WNT16
Summary
InnateDB Gene IDBG-38278.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WNT16
Gene Name wingless-type MMTV integration site family, member 16
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000002745
Encoded Proteins
wingless-type MMTV integration site family, member 16
wingless-type MMTV integration site family, member 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It contains two transcript variants diverging at the 5' termini. These two variants are proposed to be the products of separate promoters and not to be splice variants from a single promoter. They are differentially expressed in normal tissues, one of which (variant 2) is expressed at significant levels only in the pancreas, whereas another one (variant 1) is expressed more ubiquitously with highest levels in adult kidney, placenta, brain, heart, and spleen. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:121325367-121341104
Strand Forward strand
Band q31.31
Transcripts
ENST00000361301 ENSP00000355065
ENST00000222462 ENSP00000222462
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005109 frizzled binding
Biological Process
GO:0003408 optic cup formation involved in camera-type eye development
GO:0007275 multicellular organismal development
GO:0010628 positive regulation of gene expression
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016055 Wnt signaling pathway
GO:0030182 neuron differentiation
GO:0030216 keratinocyte differentiation
GO:0043616 keratinocyte proliferation
GO:0045165 cell fate commitment
GO:0046330 positive regulation of JNK cascade
GO:0046849 bone remodeling
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060548 negative regulation of cell death
GO:0090399 replicative senescence
GO:0090403 oxidative stress-induced premature senescence
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by WNT in cancer pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway
Signal Transduction pathway
WNT ligand biogenesis and trafficking pathway
GPCR ligand binding pathway
Class B/2 (Secretin family receptors) pathway
Disease pathway
KEGG
Wnt signaling pathway pathway
Hedgehog signaling pathway pathway
Melanogenesis pathway
Pathways in cancer pathway
Basal cell carcinoma pathway
INOH
GPCR signaling pathway
Wnt signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E9PH60
UniProt Splice Variant
Entrez Gene 51384
UniGene Hs.272375
RefSeq NM_016087 NM_057168
HUGO HGNC:16267
OMIM 606267
CCDS CCDS5780 CCDS5781
HPRD 05882
IMGT
EMBL AC006364
GenPept
RNA Seq Atlas 51384