Version 5.4
Homo sapiens Gene: PRMT7
Summary
InnateDB Gene IDBG-38353.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRMT7
Gene Name protein arginine methyltransferase 7
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132600
Encoded Proteins
IDBP-38355
protein arginine methyltransferase 7
IDBP-379599
protein arginine methyltransferase 7
IDBP-379600
protein arginine methyltransferase 7
IDBP-752442
IDBP-746249
IDBP-752176
IDBP-751902
IDBP-748980
IDBP-747925
IDBP-752816
IDBP-746587
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:68310974-68358563
Strand Forward strand
Band q22.1
Transcripts
ENST00000339507 ENSP00000343103
ENST00000449359 ENSP00000414716
ENST00000441236 ENSP00000409324
ENST00000566430
ENST00000561806
ENST00000566341 ENSP00000455705
ENST00000566657 ENSP00000454980
ENST00000568975 ENSP00000454776
ENST00000565745 ENSP00000456190
ENST00000569571 ENSP00000455538
ENST00000563562
ENST00000566708
ENST00000565983
ENST00000564441
ENST00000562050 ENSP00000457381
ENST00000568463
ENST00000569047 ENSP00000456848
ENST00000565356
ENST00000563520
ENST00000564050
ENST00000563608
ENST00000566687
ENST00000563443
ENST00000562456
ENST00000565761
ENST00000562381 ENSP00000456364
ENST00000567542
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008469 histone-arginine N-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0016277 [myelin basic protein]-arginine N-methyltransferase activity
GO:0035241 protein-arginine omega-N monomethyltransferase activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0035243 protein-arginine omega-N symmetric methyltransferase activity
GO:0042393 histone binding
GO:0043021 ribonucleoprotein complex binding
GO:0044020 histone methyltransferase activity (H4-R3 specific)
Biological Process
GO:0000387 spliceosomal snRNP assembly
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0016571 histone methylation
GO:0018216 peptidyl-arginine methylation
GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0030154 cell differentiation
GO:0034969 histone arginine methylation
GO:0043046 DNA methylation involved in gamete generation
GO:0043393 regulation of protein binding
GO:0043985 histone H4-R3 methylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSMUSG00000060098
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000009638
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL H3BRD3
UniProt Splice Variant
Entrez Gene 54496
UniGene
RefSeq NM_019023 NM_001290018 NM_001184824 XM_005255989 XM_006721196 XM_005255988
HUGO HGNC:25557
OMIM 610087
CCDS CCDS10866 CCDS54033
HPRD 15174
IMGT
EMBL AC020978 AC099521
GenPept
RNA Seq Atlas 54496

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca