InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PRMT7

Summary

InnateDB Protein

IDBP-379599.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRMT7

Protein Name

protein arginine methyltransferase 7

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000414716

InnateDB Gene

IDBG-38353 (PRMT7)

Protein Structure

UniProt Annotation

Function

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. {ECO:0000269PubMed:15044439, ECO:0000269PubMed:15494416, ECO:0000269PubMed:17709427, ECO:0000269PubMed:19110445}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:15494416}. Nucleus {ECO:0000269PubMed:15494416}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0016277	[myelin basic protein]-arginine N-methyltransferase activity
GO:0035241	protein-arginine omega-N monomethyltransferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0035243	protein-arginine omega-N symmetric methyltransferase activity
GO:0042393	histone binding
GO:0043021	ribonucleoprotein complex binding
GO:0044020	histone methyltransferase activity (H4-R3 specific)

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0006349	regulation of gene expression by genetic imprinting
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0016571	histone methylation
GO:0018216	peptidyl-arginine methylation
GO:0019918	peptidyl-arginine methylation, to symmetrical-dimethyl arginine
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0030154	cell differentiation
GO:0034969	histone arginine methylation
GO:0043046	DNA methylation involved in gamete generation
GO:0043393	regulation of protein binding