Version 5.4
Homo sapiens Gene: PTPRZ1
Summary
InnateDB Gene IDBG-38364.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRZ1
Gene Name protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Synonyms HPTPZ; HPTPzeta; phosphacan; PTP-ZETA; PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta
Species Homo sapiens
Ensembl Gene ENSG00000106278
Encoded Proteins
IDBP-243710
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
IDBP-385854
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:121873089-122062036
Strand Forward strand
Band q31.32
Transcripts
ENST00000393386 ENSP00000377047
ENST00000449182 ENSP00000410000
ENST00000471837
ENST00000483028
ENST00000489114
ENST00000483995
ENST00000468641
ENST00000470504
ENST00000474500
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006470 protein dephosphorylation
GO:0007409 axonogenesis
GO:0007417 central nervous system development
GO:0007611 learning or memory
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0048709 oligodendrocyte differentiation
GO:0070445 regulation of oligodendrocyte progenitor proliferation
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005887 integral component of plasma membrane
GO:0072534 perineuronal net
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000068748
View Gene Order
ENSBTAG00000012119
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.489824 Hs.604720 Hs.732404
RefSeq NM_001206838 NM_001206839 NM_002851 XM_005250519
HUGO
OMIM
CCDS CCDS34740 CCDS56505
HPRD 01481
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca