Homo sapiens Gene: MAFA
Summary
InnateDB Gene IDBG-38414.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAFA
Gene Name v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182759
Encoded Proteins
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:143419182-143430406
Strand Reverse strand
Band q24.3
Transcripts
ENST00000333480 ENSP00000328364
ENST00000528185
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007263 nitric oxide mediated signal transduction
GO:0009749 response to glucose
GO:0030073 insulin secretion
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Developmental Biology pathway
Regulation of beta-cell development pathway
Regulation of gene expression in beta cells pathway
KEGG
Type II diabetes mellitus pathway
Maturity onset diabetes of the young pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q8NHW3
TrEMBL D4Q8H3
UniProt Splice Variant
Entrez Gene 389692
UniGene Hs.521914 Hs.618989 Hs.632040
RefSeq NM_201589
HUGO HGNC:23145
OMIM 610303
CCDS CCDS34955
HPRD 14346
IMGT
EMBL AB086960 AB205138 AC105118 AY083269
GenPept AAL89527 BAC20389 BAJ04327
RNA Seq Atlas 389692