Version 5.4
Bos taurus Gene: MAFA
Summary
InnateDB Gene IDBG-648017.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAFA
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000026344
Encoded Proteins
IDBP-700787
v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000182759:
MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene (INS; MIM 176730) (Olbrot et al., 2002 [PubMed 12011435]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:2426857-2427912
Strand Forward strand
Band
Transcripts
ENSBTAT00000037397 ENSBTAP00000054350
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007263 nitric oxide mediated signal transduction
GO:0009749 response to glucose
GO:0030073 insulin secretion
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000182759
View Gene Order
ENSMUSG00000047591
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13819
Regulation of gene expression in beta cells pathway
REACT_111045
Developmental Biology pathway
REACT_13698
Regulation of beta-cell development pathway
KEGG
hsa04950
Maturity onset diabetes of the young pathway
hsa04930
Type II diabetes mellitus pathway
mmu04950
Maturity onset diabetes of the young pathway
mmu04930
Type II diabetes mellitus pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3MXT0
UniProt Splice Variant
Entrez Gene 618421
UniGene
RefSeq XM_003583022 XM_005215280
HUGO HGNC:23145
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02037472
GenPept
RNA Seq Atlas 618421

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca